Tuesday, March 12, 2013

FDA head says menu labeling 'thorny' issue

WASHINGTON (AP) ? Diners will have to wait a little longer to find calorie counts on most restaurant chain menus, in supermarkets and on vending machines.

Writing a new menu labeling law "has gotten extremely thorny," says the head of the Food and Drug Administration, as the agency tries to figure out who should be covered by it.

The 2010 health care law charged the FDA with requiring restaurants and other establishments that serve food to put calorie counts on menus and in vending machines. The agency issued a proposed rule in 2011, but the final rules have since been delayed as some of those non-restaurant establishments have lobbied hard to be exempt.

While the restaurant industry has signed on to the idea and helped to write the new regulations, supermarkets, convenience stores and other retailers that sell prepared food say they want to no part of it.

"There are very, very strong opinions and powerful voices both on the consumer and public health side and on the industry side, and we have worked very hard to sort of figure out what really makes sense and also what is implementable," FDA Commissioner Margaret Hamburg said in a recent interview with The Associated Press.

Hamburg said menu labeling has turned out to be one of the FDA's most challenging issues, and while requiring calorie counts in some establishments might make sense on paper, "in practice it really would be very hard." She did not say what specific types of establishments she was referring to.

The challenges of putting such a law in place ? and deciding whom it should apply to? were made clear Monday when a judge struck down New York City's ban on large sugary drinks. State Supreme Court Justice Milton Tingling said in his ruling that the 16-ounce limit on sodas and other high-calorie drinks arbitrarily applied to only some sweet beverages and some places that sell them. The new limits, championed by Mayor Michael Bloomberg, were supposed to take effect Tuesday.

Hamburg said the FDA is in the final stages of writing the menu labeling regulations and the final rules should come out in the "relative near term." The FDA has tentatively said the rules are due this spring, but that deadline may be optimistic as the food industry and regulators continue to haggle over how they will be written.

The 2011 proposed rules would require chain restaurants with 20 or more locations, along with bakeries, grocery stores, convenience stores and coffee chains, to clearly post the calorie count for each item on their menus. Additional nutritional information would have to be available upon request. The rules would also apply to vending machines if calorie information isn't already visible on the package.

The proposed rules exempted movie theaters, airplanes, bowling alleys and other businesses whose primary business is not to sell food. Alcohol would also be exempted.

Supermarkets and convenience stores are looking for similar exemptions in the final rules. Representatives for the supermarket industry say it could cost them up to a billion dollars to put the rules in place ? costs that would be passed on to consumers.

"It's a huge problem for us," says Erik Lieberman of the Food Marketing Institute, which represents retail grocery chains. He says fighting the menu labeling rules is one of his group's top priorities.

Lieberman says the rules could cover thousands of items in each store, going beyond just the prepared foods case and extending to cut fruit, bakery items like pies and loaves of bread and other store items that aren't already packaged and labeled. Lieberman says that means each store has to send all of those items out to labs to be tested, do paperwork to justify the ingredient and nutritional information for each item to the FDA and then create signage and train employees to use it.

Convenience stores say they will have similar problems.

"In a small store like a convenience store that is really putting a lot of signage all over the place," says Jeff Lenard of the National Association of Convenience Stores, referring to the calorie labels. "You just hit a point where words become noise and that's not good."

Nutrition lobbyist Margo Wootan of the Center for Science in the Public Interest says consumer advocates heard the same kind of complaining from the packaged foods industry before they were required to put nutrition information on the backs of food items. Supermarkets and convenience stores should be included because they are breaking more and more into the prepared foods business, she says.

"The supermarket industry is positioning itself as a place to buy prepared items so you don't have to go out to eat or cook," she says, arguing that a rotisserie chicken that is labeled with a calorie count at a takeout restaurant should also be labeled at a grocery store.

The idea of menu labeling is to make sure that customers process the calorie information as they are figuring out what to eat. Many restaurants currently post nutritional information in a hallway, on a hamburger wrapper or on their website. The new law will make calories immediately available for most items.

Menus and menu boards will also tell diners that a 2,000-calorie diet is used as the basis for general nutrition advice, noting that individual calorie needs may vary.

The labeling requirements were added to the health bill with the support of the restaurant industry, which has faced a patchwork of laws from cities and states. New York City was the first in the country to put a calorie posting law in place. Since then, other cities and states have followed.

Scott DeFife of the National Restaurant Association says the supermarkets are exaggerating how much it would cost them to implement the rules. The restaurant industry has lobbied for the prepared foods in supermarkets and convenience stores to be included, saying they are selling essentially the same things.

DeFife says some convenience stores have even joined the National Restaurant Association as many gas stations now include full restaurants in their stores.

"It's about the food, not the format," he says.

Not all restaurants have been fully supportive, though. A coalition of pizza chains ? including Domino's, Papa John's and Pizza Hut franchise holders ? have pushed for changes to the proposed rules that would allow more flexibility in how calories are posted because of endless combinations of pizza toppings. The coalition claims there are 34 million ways to order a pizza.

"When you're a small pizza operator trying to get by on tight margins, regulations like this really affect your bottom line, hurting your ability to grow and hire," Domino's Pizza franchisee Jonathan Sharp of Abilene, Texas, said last summer.

___

Follow Mary Clare Jalonick on Twitter at http://twitter.com/mcjalonick

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-03-12-Calories%20on%20Menus/id-dd6f650bf1a34e689dea591076e8caf6

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My upcoming book: Apothecary Cocktails, Restorative Drinks from ...

Author of upcoming book: Apothecary Cocktails-Restorative Drinks from Yesterday and Today on Rockport/Quayside Books, now in pre-sale on Amazon. Warren Bobrow is the cocktail writer for Foodista. Warren Bobrow is the Food and Drink Editor of the 501c3 non profit Wild Table on Wild River Review located in Princeton, New Jersey. Warren was one of only 12 journalists world-wide, and the only one from the USA to participate in the F?te de la Gastronomie- the weekend of September 22nd. 2012 in Burgundy and Paris. He attends Tales of the Cocktail and is presenting on Milk Punch for the 2013 show Warren demo'd freestyle mixology at the International Food Bloggers Conference in Portland, Oregon. (2012) Warren judged the Iron Mixology competition at the Charleston Wine and Food Festival (2012) Warren has published over three hundred articles on everything from cocktail mixology to restaurant reviews to travel articles. You may find him on the web at: http://www.cocktailwhisperer.com Warren is a published food writer and worked for Jim Ledue at Alberta's in Portland, Maine as a cook. Warren began his climb to becoming a chef as a pot scrubber at the York Harbor Inn in York Harbor, Maine in 1985. Warren is the former owner and co- founder of Olde Charleston Pasta in Charleston, SC while cooking at the Primerose House and Tavern. (Also in Charleston) He spent Hurricane Hugo (1989) in his former home in Charleston and lost his business soon thereafter. Warren was # 30 in Saveur Magazine's 100 in 2010, for his writing about the humble Tuna Melt. He's written food and cocktail articles and news for Edible Jersey, Chutzpah Magazine, Voda Magazine, Tasting Table, Serious Eats and Total Food Service Magazine. Warren attended the Kentucky Derby and the Oaks Day Races 2012, while on assignment for Voda Magazine. He writes for the "Fabulous Beekman 1802 Boys" as their cocktail writer. (Klaus, The Soused Gnome) He also writes for The Daily Basics, Leaf Magazine and Modenus. He writes for Williams-Sonoma on their Blender Blog. He is a Ministry of Rum judge.

Source: http://cocktailwhisperer.com/?p=326

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Psychedelic glowing wings give planes a lift

Sandrine Ceurstemont, editor, New Scientist TV

You could soon see glowing objects in the sky: psychedelic planes are being developed. The aim is better aerodynamics, though, rather than messing with your mind.

Plasma, which makes neon lights glow, can also create jets of air to help propel small planes when generated over wings. In this video, captured by Navid Nayeri and colleagues at the Technical University of Berlin, Germany, the effect on the airflow is visible on a test wing as it extinguishes the flame from a lighter. Another clip, captured in a wind tunnel, shows how ionised gas can help regain lift. The wing is placed at a high angle of attack, a position in which it often experiences loss of lift. But the flow is excited when the plasma is turned on, allowing the wing to rise up again. The wing is loosely mounted in this demo to make the difference in lift visible.

In addition to its use in planes, plasma could also help reduce drag in cars or wind turbines. For more about the aerodynamic effect of "ion winds", read our feature, "Glow planes: Plasmas take the drag out of air travel".

If you enjoyed this post, watch a video that debunks the common misconception of how wings create lift or check out a new plasma engine that could power trips to Mars.

Subscribe to New Scientist Magazine

Source: http://feeds.newscientist.com/c/749/f/10897/s/297115e9/l/0L0Snewscientist0N0Cblogs0Cnstv0C20A130C0A30Cpsychedelic0Eplasma0Ewings0Bhtml0Dcmpid0FRSS0QNSNS0Q20A120EGLOBAL0Qonline0Enews/story01.htm

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Friday, March 8, 2013

Jobs Extra 7th March 2013 | Equality Updates


Other jobs sites to check out
http://www.goodmoves.org.uk
http://www.senscot.net/jobs.php
http://www.voluntaryarts.org
http://www.acvo.org.uk/jobs.html
http://www.creativescotland.com/jobs/current
https://www.myjobscotland.gov.uk
http://www.evenbreak.co.uk
http://www.proudemployers.org.uk/
http://www.inclusivejobs.com/

Volunteering Opportunities: http://www.volunteerscotland.org.uk/

CONTENTS:

+1 KEZIA DUGDALE MSP: One Internship, Edinburgh
Paid Internship (Gender Equality & Gender Based Violence): 3 months, 8 hours a week (over 1 or 2 days), ?7.45 an hour

+2 IRISS: One Post, Glasgow
Project Manager, Innovation and Improvement: ?29,541 ? ?36,928

+3 CAB EASTERHOUSE: One Voluntary Post, Glasgow
Volunteer Advice Worker

+4 SDSS: Roadshow ? Glasgow, Edinburgh, Perth, Aberdeen
SDS Personal Assistants Employment Roadshows

+5 OUTSIDE THE BOX: Voluntary Posts, Glasgow
Mind Waves ? Community Reporters

+6 SAY WOMEN: One Post, Glasgow
Female Housing Support Worker: 28 Hrs per week, ?20,520 pro rata

+7 ONE PARENT FAMILIES SCOTLAND: One Post, Edinburgh
Contracts and Monitoring Officer: ?23,232 ? ?28,866.

+8 LGBT HEALTH: Various Voluntary, Edinburgh
Become an LGBT Age Community Champion!

+9 WEST OF SCOTLAND REGIONAL EQUALITY COUNCIL: One Post, Glasgow
IT and Information Officer: ?18,775 pa pro rata (22.5 hours per week)

+1

KEZIA DUGDALE MSP

PAID INTERNSHIP (Gender Equality & Gender Based Violence)

3 months, 8 hours a week (over 1 or 2 days) paid at the current living wage of ?7.45 an hour.? At least one of the days worked should be a Parliament ?business day? (Tuesday ? Thursday).

Internship 1st April ? 21st June 2013

THEME: Gender Equality & Gender Based Violence

APPLICATIONS: Welcome between 6th March and 20th March 2012

CVs accompanied by a covering note should be sent to Kezia.Dugdale.msp@scottish.parliament.uk during this period.

IDEAL FOR: People with an interest in Gender and Equality based social policy. The successful applicant will work in conjunction with Zero Tolerance to organise an event in the Scottish Parliament which will include key note speeches from leading campaigners on Gender issues. Naturally this opportunity is open to both men and women.

INTERVIEWS: 27th March 2013 in conjunction with Zero Tolerance.

More details at: http://www.keziadugdale.com/biography/intern/

+2

IRISS

PROJECT MANAGER, INNOVATION AND IMPROVEMENT

Glasgow
(2 years, fixed term with possible extension)
?29,541 ? ?36,928

We are currently seeking a Project Manager who has experience of delivering in the public sector and has skills in co-design methods to work in our Innovation and Improvement team. We are looking for a self-starter with a passion for using their design skills to improve the way people access support.? You will work in partnership to develop, design and deliver frameworks, tools and techniques to promote and embed innovation and service improvement with support providers across Scotland.? It is a creative role that requires you to generate ideas, organise and support activities, employ new approaches to project delivery and engage effectively with a range of stakeholders. For more information go to
http://www.iriss.org.uk/jobs/project-manager-innovation-and-improvement

+3

CAB EASTERHOUSE

VOLUNTEER ADVICE WORKER

Provide a front line service to clients of CAB Easterhouse. Assist local people with a wide range of issues and participate in excellent training and development opportunities. After training we will need you for 2 x 4 hour sessions per week. If you are over 18 years old please get in touch if you are interested in this opportunity. Our next training starts on 16th April 2013.

http://www.volunteerglasgow.org/uncategorized/volunteer-advice-worker/

+4

SDSS

SDS PERSONAL ASSISTANTS EMPLOYMENT ROADSHOWS

Wednesday 13th March ? Glasgow ?Thistle Hotel
Tuesday 9th April ? Edinburgh ? Norton Park Conference Centre
Wednesday 10th April ? Perth ? Perth Concert Hall
Tuesday 16th April ? Aberdeen ? Aberdeen Exhibition Conference Centre

This event is funded by the Scottish Government and is being run by SDSS and SPAEN. The theme is Personal Assistant Employment. The same event will run in 4 different locations around Scotland and is therefore being termed ?SDS PA Employment Roadshow?.

PA Employment is one part of self-directed support and these events focus on developing people?s confidence and knowledge in this specific area.? It will be a chance for Local Authority workers, prospective PA Employers and prospective PAs to learn more about this option and the pros and cons that come along with it. Existing PA Employers and PAs are also encouraged to attend and there will be workshops available to all on the day. For Personal Assistants there will be a workshop run by UNISON and Glasgow Centre for Inclusive Living on the rights and responsibilities of PAs. There will also be a workshop for Local Authority reps as well as a general Q&A session at the end.

If you would like to attend any of these events please fill out this booking form and send it back to us at info@sdsscotland.org.uk. Please see the programme here: http://www.sdsscotland.org.uk/showlog.php?weblogid=126

+5

OUTSIDE THE BOX

MIND WAVES ? COMMUNITY REPORTERS

Positive news about mental wellbeing

Mind Waves is an innovative project promoting mental health and wellbeing through positive use of the media.

We offer:
Support for people who want to create and share news stories about activities which promote mental wellbeing
Focus on collective efforts, where groups of people have got together to promote mental wellbeing
A way for community groups and projects to get across their own message about mental wellbeing.

Volunteers

Mind Waves aims to raise public awareness about mental wellbeing and recovery and what makes a healthy community for everyone. We use a range of ways to promote our message ? community newsletters, sharing items with your own networks or groups, blogs and newspaper articles, and are now moving into community radio and internet sites such as YouTube.

We have also produced tips and hints for other people to share their stories.

We recently produced a flyer to tell people what we have achieved so far and what our plans are for the next stage of the project.

Mind Waves is supported by NHS Greater Glasgow and Clyde and their partners.

Community Reporters:

Mind Waves is built around the work of our Community Reporters. The volunteers get training and support to identify and produce stories or more visual ways of getting the message over.

Interested in becoming a Mind Waves Community Reporter?

We?re RECRUITING NOW!

Mind Waves is recruiting a new group of volunteers to train as Community Reporters. If you?re interested please contact us at admin@otbds.org.

Outside the Box has been commissioned by NHS Greater Glasgow and Clyde to support the development of Mind Waves and the Community Reporters involved in the project. Mind Waves works in partnership with a wide variety of groups, agencies and individuals who share a commitment to its aims, and a multi-agency Steering Group guides its development, with representatives from mental health service user organisations and the Community Reporters themselves.

+6

SAY WOMEN

SAY Women is a voluntary organisation which provides supported accommodation and related services for young women survivors of childhood sexual abuse and rape/sexual assault who are homeless or at risk of homelessness.

1 FEMALE HOUSING SUPPORT WORKER (28 HOURS) ? AP3 (?20,520 pro rata).
12 MONTHS CONTRACT INITIALLY.

This is a new post within our Accommodation Project aimed at focusing on practical living skills and engagement with external agencies for 8 young women. Experience in providing this type of practical support to vulnerable groups is essential. Experience of working with survivors of childhood sexual abuse is also preferred but full training will be provided for anyone with the right attitude and approach who would like to work in this field.

The post is exempt under Schedule 9 of the Equality Act 2010 and subject to PVG disclosure checks.

For an application pack, contact Roselyn Smith, SAY Women, 3rd Floor, 30 Bell Street, Glasgow G1 1LG, call 0141 552 5803 email: enquiries@say-women.co.uk.

Closing date: Monday 18th March 2013

+7

ONE PARENT FAMILIES SCOTLAND

Edinburgh

CONTRACTS AND MONITORING OFFICER
35 hours per week, Salary: SJC points 27 to 34, ?23,232 to ?28,866.

We are seeking a Contracts and Monitoring Officer to join our core team. The successful applicant will have experience of the development and implementation of monitoring and evaluation systems and processes, and information analysis.

Closing Date for applications 9am on 25 March 2013

Further details and application forms available from our website http://www.opfs.org.uk/get-involved/vacancy/625 or email rory.ross@opfs.org.uk

Rory Ross, One Parent Families Scotland, 13 Gayfield Square, Edinburgh, EH1 3NX Telephone: 0131 556 3899.

OPFS aims to be a family friendly and equal opportunities employer.

+8

LGBT HEALTH

Become an LGBT AGE COMMUNITY CHAMPION!

[Edinburgh]

Community Champions with the LGBT Age Capacity Building Project come from all walks of life, all backgrounds and can be of any age. We are looking for additional team members to join our existing Community Champions in working older LGBT people to confront prejudice and isolation amongst this often invisible community.? Do you enjoy writing? Join our blogging team; Do you have experience of training or providing presentations?; Would you be able to help organise a medium size conference with a team of other volunteers?? You?ll be part of a small volunteer team working to make sure both older LGBT people and organisations across Edinburgh are aware of the unique challenges faced by older LGBT people.? Get in touch with Stefan Milenkovic on 0131 523 1102 or email: stefan@lgbthealth.org.uk

+9

WEST OF SCOTLAND REGIONAL EQUALITY COUNCIL

IT AND INFORMATION OFFICER

?18,775 per annum pro rata (22.5 hours per week)
Closing Date:? 5.00pm Wednesday 20th of March 2013

Interviews will be held on Wednesday 3rd of April 2013

For more information please click on the link below
http://wsrec.co.uk/index.php/vacancies/jobs

^^^^^^^^^^^^^^^
^^^^^^^^^^^^^^^

The EQUALITY UPDATES e-newsletter is produced on behalf of the Glasgow Equality Forum.

The Forum is made up of representatives from the following voluntary sector networks and equality organisations: Glasgow Black and Ethnic Minority Voluntary Sector Network; Glasgow Disability Alliance; West of Scotland Lesbian, Gay, Bisexual and Transgender Forum; Glasgow Women?s Voluntary Sector Network; Age Scotland; LGBT Youth Scotland; Faith in Community Scotland; Scottish Refugee Council, and from the following public sector bodies: Strathclyde Police; NHS Greater Glasgow & Clyde (Equalities In Health); GCC Chief Executive?s Office; Glasgow Community and Safety Services; GCC Community Planning Partnership; Glasgow Housing Association (GHA)

This message may contain information that has been sent to the Glasgow Equality Forum Communications and Resource Worker by third parties.? While we do everything possible to ensure the transmission of accurate and appropriate material, we do not take responsibility for its content.? The forwarding of information to you should not be seen as an endorsement of any of the views expressed.

If you have been forwarded this e-newsletter but would like to subscribe directly to EQUALITY UPDATES, FUNDING EXTRA and/or JOBS EXTRA simply email kate.henderson@gcvs.org.uk

If you wish to unsubscribe from this email list please email: kate.henderson@gcvs.org.uk with the message ?unsubscribe? in the subject line.

Contact details: Kate Henderson, Glasgow Equality Forum Communications and Resource Worker, Glasgow Council for the Voluntary Sector, 11 Queens Crescent, Glasgow G4 9AS Tel: 0141 332 2444 Fax: 0141 332 0175 Email: kate.henderson@gcvs.org.uk

08. March 2013 by admin
Categories: jobs extra, weekly newsletters | Leave a comment

Source: http://enf.org.uk/blog/?p=4227

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Disney ups box-office ante on "Oz" with massive foreign rollout

LOS ANGELES (TheWrap.com) - Domestic box-office projections for the debut weekend of "Oz the Great and Powerful" are going as high as $85 million, and Disney's prequel to the 1939 classic could do even better than that overseas.

The studio will roll out its 3D CGI extravaganza in nearly every major foreign territory this weekend - France comes next week, China on March 29 - and analysts say it could exceed its domestic haul at the international box office. It debuts Thursday in 27 territories, including Russia, Germany, Australia, South Korea and Italy. By Friday it will be in 46 markets, including openings in the U.K., Japan, Mexico, Spain and Brazil.

The domestic and foreign debuts make this first weekend critical for Disney, which has very much front-loaded its box-office gamble on "Oz," which carries a $200 million production budget and a marketing budget at least half that size.

Disney's head of distribution Dave Hollis acknowledged that the stakes are high.

"With the Disney brand and an iconic, revered property like this, of course it's a big bet," Hollis told TheWrap. "But when you ally yourself with filmmakers like Sam Raimi and Robert Stromberg, you reduce some of the risks. We feel really good about this."

Raimi, director of the first three "Spider-Man" movies, is at the helm of "Oz." James Franco stars as a circus magician sucked via tornado to Oz, where the residents mistake him for a wizard who will free them from the wicked witches. Mila Kunis, Michelle Williams and Rachel Weisz co-star.

Stromberg is the production designer, and had the same role on the film most often compared with "Oz," the similarly big-budget and effects-laden "Alice in Wonderland." That Disney film starred Johnny Depp and made more than $1 billion in 2010, with the vast majority - $690 million - coming from abroad.

As a literary work, "Alice in Wonderland" is more well-known globally than "The Wizard of Oz," a very American property. But even "John Carter," the mega-budget sci-fi adventure flop that resulted in a $200 million write down for Disney last year, took in $209 million overseas, compared to $73 million domestically.

'I think 'Oz' is a much better bet to open with $100 million overseas than in the U.S.," Exhibitor Relations senior vice-president and senior analyst Jeff Bock told TheWrap.

"Oz" will debut Friday in 3,912 North American theaters. Around 3,055 of those will be 3D, and 307 will be Imax theaters, both of which will be charging premium prices.

Families - who largely steered clear of Warner Bros.' similarly pricey CGI epic "Jack the Giant Slayer" last week - are expected to turn out in force for "Oz." Its PG rating will help there, though parents should know there are some intense moments - heightened by the 3D - that caused at least one 5-year-old to jump into her father's lap three times during a screening.

TheWrap's reviewer Alonso Duralde loved it, but "Oz" has only a lukewarm 62 percent positive rating on Rotten Tomatoes (the more telling number there may be the 99 percent "want to see" figure). Movie Review Intelligence has it at 54 percent positive.

"Oz" has accounted for nearly 80 percent of the presales at online ticket broker Fandango this week and, in a positive sign for Disney, 66 percent of those responding to a survey on the site said they would bring their families.

"Oz the Great and Powerful" isn't the only movie opening this week.

Colin Farrell and Noomi Rapace ("Prometheus") star in Film District's neo-noir revenge thriller "Dead Man Down." Farrell plays a man who has infiltrated the crime empire run by a ruthless kingpin (Terence Howard) for his own very definite reasons, while his neighbor (Rapace) wants his help to carry out her own plans for retribution.

Danish filmmaker Niels Arden Oplev, who directed Rapace in the original "Girl With the Dragon Tattoo," makes his U.S. debut on the film.

Farrell's has underwhelmed in his last two outings as a leading man. "Seven Psychopaths" was a critical fave but opened to just $4 million in October and topped out at $28 million for CBS Films. And no one forgot Arnold Schwarzenegger after Farrell's turn in last summer's "Total Recall" remake, which slogged to a $59 million domestic total for Sony.

J.H. Wyman (TV's "Fringe") wrote the screenplay and produced via Frequency Films with Neal H. Moritz's Original Film. IM Global financed the $30 million movie. Film District has the R-rated thriller in 2,188 theaters and projections are for an opening in the $5 million range.

On the specialty front, Roadside Attractions is rolling out director Peter Webber's historical war drama "Emperor," which stars Tommy Lee Jones, Matthew Fox and rising Japanese star Eriko Hatsune.

Set in post-World War II Japan, during the American occupation, the PG-13 rated "Emperor" is based on the real-life drama behind the decision of whether to try Emperor Hirohito for war crimes. Jones plays Gen. Douglas MacArthur - the de facto ruler of Japan - and Fox plays Gen. Bonner Fellers, who lead the investigation of Hirohito.

It will be in 259 theaters, mostly in the top 75 markets.

IFC Films will debut the drama "Beyond the Hills," Romania's nominee for the Best Foreign Language Oscar, in three theaters.

The film is directed by Cristian Munglu and stars Cristina Flutur and Cosmina Stratan as two young women at an Orthodox convent in Romania. It premiered at Cannes last year where Munglu won the award for best screenplay and Flutur and Stratan shared best actress honors.

Cinedigm is releasing "Don't Stop Believin': Everyman's Journey" in 20 theaters nationwide. It's a documentary on Arnel Pineda, who was plucked from YouTube to become the new singer for the rock band Journey.

The "ABCs of Death" is an anthology horror film from Magnolia Pictures produced by Ant Timpson and Tim League that will debut in about 20 theaters. It's made up of 26 different shorts, each by different directors, all dealing with death. It premiered at last year's Toronto Film Festival and has been out on video on demand since January.

Source: http://news.yahoo.com/disney-ups-box-office-ante-oz-massive-foreign-000552499.html

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14 Silly Items Found in Car Owner's Manuals

Sorry, Readability was unable to parse this page for content.

Source: http://www.popularmechanics.com/cars/news/industry/14-silly-items-found-in-car-owners-manuals?src=rss

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Home Goods, Home Improvement, Home Decor, Home Design ...

#1 Secret: A quality roller ? I kid you not! Do not buy one of the cheap rollers commonly found in the big box stores. ?Buy it where real pro?s buy there supplies ? specialty paint stores. We are talking pennies ? but do yourself a big favor: Get a quality dripless roller (3/8? nap works well for most walls). Quality rollers are the first step to a quality paint job.

#2 Secret: VOC free paint ? even low VOC paint still significantly affects your body.? I recently painted a room with low VOC paint, thinking it was good enough? ?immediately I got myself a big headache. Our bodies are being pounded by environmental factors ? give your body and the planet a break and work ONLY with VOC free paint?again, only pennies more.

#3 Secret: The right quality primer to cover different paints ? Benjamin Moore makes great paint, AND they offer a selection of primers for different applications.

For example: Their 046 primer allows you to paint over previously used oil paints with water based paints!

This is HUGE ? who ever thought you could switch to water-based products. In the past, painters would tell you, once you select oil-based paint you have to stay with just that? oil based paints. Not so any longer!? A true breakthrough!

Back To Home Page

Source: http://www.sabineshome.com/3-simple-pro-home-improvement-secrets-costing-pennies/

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Sunday, March 3, 2013

Cancer vaccines self-sabotage, channel immune attack to injection site

Mar. 3, 2013 ? Cancer vaccines that attempt to stimulate an immune system assault fail because the killer T cells aimed at tumors instead find the vaccination site a more inviting target, scientists at The University of Texas MD Anderson Cancer Center report in Nature Medicine.

A common substance used in many cancer vaccines to boost immune attack betrays the cause by facilitating a buildup of T cells at the vaccination site, which then summon more T cells to help with the perceived threat.

"Vaccines stimulate production of T cells primed to attack the target cancer, and there are many T cells in the bloodstream after vaccination. We found that only a few get to the tumor while many more are stuck at or double back to the vaccination site," said senior author Willem Overwijk, Ph.D., in MD Anderson's Department of Melanoma Medical Oncology.

The result: largely unscathed tumors while an overstimulated immune response can cause lesions at the injection site. The team found that a major culprit in this failure is incomplete Freund's adjuvant (IFA), a mineral oil-based adjuvant included in many vaccines to stoke the immune response.

"IFA sticks around the vaccination site for up to three months, along with the antigen designed to trigger immunity against the tumor," Overwijk said. "T cells keep attacking and secreting chemokines to call for reinforcements. But it's an unkillable target; T cells can't kill mineral oil."

Eventually, the T cells die. "The vaccination site increasingly resembles a viral infection, with lots of damaged tissue and antigens," Overwijk said.

Switch from IFA to saline adjuvant reverses effect

"Switching to a saline-based adjuvant in a melanoma vaccine reversed the T cell effect in mice," Overwijk said, "Major accumulations of T cells gathered in tumors, shrinking them, with minimal T cell activity at the vaccination site."

Peptide antigens are available for almost all types of cancer, Overwijk said. A saline adjuvant could change the poor performance of cancer vaccines.

A clinical trial of the concept is expected to open later this year led by Craig Singluff Jr., M.D., professor of surgery at the University of Virginia Medical School, and Patrick Hwu, M.D., chair of MD Anderson's Department of Melanoma Medical Oncology.

Overwijk and colleagues noted 98 federally approved U.S. clinical trials of vaccines against a variety of cancers have almost all failed, while another 37 trials are open, enrolling patients. The U.S. Food and Drug Administration has approved only one therapeutic vaccine, for treatment of prostate cancer, out of all of those trials.

"Our group and many other researchers have been trying for years to improve the performance of cancer vaccines, to no avail," Overwijk said. "People kept trying because of these beguiling T cell levels in the blood. But our data suggest that the very nature of IFA-based vaccines may make it almost impossible for them to work well."

In past experiments and clinical trials, tumors were rarely examined for evidence of T cell penetration. In people, they are often inoperable, and there was no indication that it needed to be done. "But a few researchers did analyze human tumors for T cell infiltration and largely found what we found in our mouse experiments," he said.

Mouse studies reveal vaccine self-sabotage

The team studied the fate of melanoma-specific CD8-positive T cells after vaccination with the gp100 peptide with and without IFA.

Both vaccines increased levels of the desired T cells in the blood, but with IFA, the T cells dropped to nearly undetectable levels after three weeks and did not rebound even with an engineered virus-based booster. The vaccine-lacking IFA produced similar peak amounts of the T cells, a response that persisted over time.

The research team fluorescently tagged T cells in the mouse model to see where they went.

* Mice without IFA had the bulk of T cells light up in their tumors with minimal presence at the vaccination site.

* T cells built up at the injection site in mice that received IFA-based vaccine, with a tiny showing in the tumor.

Response duration was tested in gp100/IFA and control IFA vaccines. The antigen/IFA combination gathered and persisted at the vaccination site, where it could still stimulate the proliferation of injected T cells 96 days after vaccination.

A separate set of experiments showed the antigen/IFA-driven T cells were forced to kill themselves at the vaccination site by a variety of cell suicide-inducing proteins.

Reducing vaccine depots at injection site

Overwijk and colleagues inferred that a possible answer to the problem was to reduce the size and persistence of vaccine "depots" at the injection site.

They tested a vaccine based on a saline solution instead of IFA and found that antigens cleared more quickly but did not spark the desired T cell response. A combination of three stimulatory molecules (covax) was added to the saline/peptide vaccine, producing a strong T cell response. IFA/peptide vaccine produced a strong T cell response but also stronger post-peak T cell suicide.

A comparison of saline/peptide/covax vs. IFA/peptide/covax showed the saline version caused T cells to home to the tumor and destroy them, while the IFA version focused T cells at the vaccination site, killing normal tissue and inducing chemokines that damaged and killed T cells.

"IFA-based vaccination sites essentially outcompete tumor sites for T cell recognition and accumulation, chemokine production and tissue damage," Overwijk said. "It's an engineering flaw in those vaccines that we didn't appreciate until now. Fortunately, our results also directly instruct us how to design new, more powerful vaccine formulas for treating people with cancer."

Co-authors are first author Yared Hailemichael, Zhimin Dai, Nina Jaffarzad, Yang Ye, Miguel Medina, Xue-Fei Huang, Stephanie Dorta-Estremera Nathaniel Greeley, , Giovanni Nitti, Weiyi Peng, Chengwen Liu, Yanyan Lou, Brian Rabinovich and Patrick Hwu, all of MD Anderson's Department of Melanoma Medical Oncology; Zhiqiang Wang, Wencai Ma, and Richard Davis, of MD Anderson's Department of Lymphoma and Myeloma; and Kimberly Schluns, of MD Anderson's Department of Immunology.

Dorta-Estremera, Greeley, and Nitti are graduate students in The University of Texas Graduate School of Biomedical Sciences, a graduate school operated jointly by MD Anderson and The University of Texas Health Science Center at Houston. Schluns, Davis, Hwu and Overwijk also are on the GSBS faculty.

Grants from the National Cancer Institute of the National Institutes of Health (RO1 1CA143077 and PO1 CA128913) and an award from the Melanoma Research Alliance funded this research.

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The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yared Hailemichael, Zhimin Dai, Nina Jaffarzad, Yang Ye, Miguel A Medina, Xue-Fei Huang, Stephanie M Dorta-Estremera, Nathaniel R Greeley, Giovanni Nitti, Weiyi Peng, Chengwen Liu, Yanyan Lou, Zhiqiang Wang, Wencai Ma, Brian Rabinovich, Kimberly S Schluns, Richard E Davis, Patrick Hwu & Willem W Overwijk. Persistent antigen at vaccination sites induces tumor-specific CD8 T cell sequestration, dysfunction and deletion. Nature Medicine, 03 March 2013 DOI: 10.1038/nm.3105

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/5G8LVFGFTII/130303154855.htm

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Facebook scoops up Atlas. More social ads incoming?

Facebook bought Atlas, an advertising tracking and management company, from Microsoft this week for an undisclosed sum. Facebook is likely hoping to improve the precision of its own ads, and perhaps to launch an ad network to rival Google's.

By Jeff Ward-Bailey,?Contributor / March 1, 2013

Facebook purchased ad company Atlas from Microsoft this week, and could be working on creating its own ad network. Here, a mural at Facebook's California headquarters stylizes the code on which the social network runs.

Paul Sakuma/AP/File

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Facebook has a mountain of data on its users? activities, locations, and other data -- which allows it to serve up advertisements that are pretty narrowly tailored to individual tastes. Now that ad-focusing ability could get even better.

Skip to next paragraph Jeff Ward-Bailey

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Jeff began writing for the Monitor's Horizons blog in 2011, covering product news and rumors, innovations from companies like Apple and Google, and developments in tech policy.

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On Thursday, the company announced it will buy Microsoft?s ?Atlas,? an business that helps companies buy, manage, and track ads.

What will Atlas do for Facebook? Neither company has laid out specific plans yet, but the first part of the theory is that better data will lead to more advertising dollars. Facebook has been working for a while to increase its ad revenue -- especially on tablets and phones -- and Atlas brings some powerful data tracking features to the table, which would allow Facebook to better measure how effective its ads are.

Peter Kafka at AllThingsD predicts (based on intel from ?smart folks who have some skin in the game?) that once Facebook can prove the value of its ads, it?ll be able to increase ad pricing.

This is important to Facebook, because Atlas is a direct competitor to Google?s ad service -- and right now, Google is eating Facebook?s lunch. DoubleClick can better quantify the success of its ads, and because of this, lots of companies choose to advertise with Google (which means the company can charge more for ads). Atlas could give Facebook the same kind of leverage.

Atlas brings another strength to Facebook: It lets advertisers target ads even more closely, based on the social habits of Facebook users. In other words, advertisers will be better able to understand the relationship between the things you do (as captured by Facebook) and the things you buy, and can capitalize on this information. Eventually, this could lead to Facebook developing an ad network and selling ads outside of its own site. And because the company has such a vast amount of data on what things people are sharing and ?liking,? a Facebook-driven social ad network would likely be pretty effective.

Atlas has been around for awhile. Microsoft acquired the company in 2007 when it bought the advertising firm aQuantive for $6 billion. That purchase proved to be ill-fated: Microsoft ultimately wrote off most of the acquisition cost, and has apparently been trying to sell Atlas for some time. In October, Jason del Rey reported in AdAge that Microsoft was working to sell it to New York ad company AppNexus.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/cdVZ7citenk/Facebook-scoops-up-Atlas.-More-social-ads-incoming

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The Engadget Interview: Chul Bae Lee, VP of LG's mobile design lab at MWC 2013

The Engadget Interview Chul Bae Lee, VP of LG's mobile design lab at MWC 2013

We first met Chul Bae Lee -- VP of LG's mobile design lab -- in Seoul last fall and were lucky to spend a few minutes with him in the company's booth at MWC. LG's flagship Optimus G Pro made quite the splash in Barcelona but looks rather different from the Optimus G. We asked Mr. Lee to walk us through the design process behind the company's new superphone. He mentioned that LG offers two high-end product lines, one focused on premium design (Optimus G), the other on high-performance design (Optimus G Pro) and shared a diagram with us to illustrate this (after the break). The new handset puts an emphasis on ergonomics rather than style by featuring a comfortable and a friendly shape, with soft edges and round corners.

We discussed the extremely narrow display bezel, striking RGB notification ring around the home button, recessed camera lens and IR blaster (for the QRemote functionality). Mr. Lee explained that the placement of the buttons around the Optimus G Pro was carefully chosen to minimize interference with the power / lock key -- this includes the QNote button, which can be remapped to invoke other apps, and even double as a shutter key. We then talked about the new Optimus F series, which blends the design DNA of flagship devices with performance specs (like LTE) at a more affordable price, and the Optimus L II line, which offers unique designs for specific markets (single SIM in Europe, and dual-SIM in Latin America). Hi the break for our video interview and to check out the aforementioned design diagram.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/-hj-LO6eNFM/

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